Substituent effects on the genotoxicity of 4-nitrostilbene derivatives
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چکیده
منابع مشابه
Substituent effects on the genotoxicity of 4-nitrostilbene derivatives.
4-Nitrostilbene and twelve of its derivatives (eleven E-stilbenes and two Z-stilbenes) were examined for possible quantitative structure-activity relationships of their in vitro and in vivo genotoxicity. Relative mutagenicity was studied with and without S9 activation in Salmonella strains TA98 and TA100, as well as in the nitroreductase deficient strains TA98/NR and TA100/NR. Chromosomal aberr...
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4-Amino-4'-substituted biphenyls and 4-aminostilbenes substituted in the 3' or 4' position were studied for their in vitro and in vivo genotoxicity. The in vitro mutagenicity of the biphenyls with and without S9 activation was established with Salmonella strains TA98 and TA100 and that of the stilbenes with the same strains plus TA98/1,8-DNP6. The in vivo genotoxicity assay with both series of ...
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ژورنال
عنوان ژورنال: Mutation Research/Genetic Toxicology
سال: 1994
ISSN: 0165-1218
DOI: 10.1016/0165-1218(94)90024-8